Yearly Archives: 2021

Happy New Year!

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Decorative photograph of sculpture of a skeletal person leading a skeletal dinosaurThis year I have written about 20,000 words in 52 posts (including this one); and, since this is the last post of the year, I thought I would take a brief look back at what has preoccupied me in 2021.  Perhaps, not surprisingly the impact of the coronavirus on our lifestyle has featured regularly – almost every week for a month between mid-March and mid-April when we were in lockdown in the UK.  However, the other topics that I have written about frequently are my research on the dynamics of nanoparticles and, in the last six months, on dealing with uncertainty in digital engineering and decision making.  I have also returned several times to innovation processes and transitioning lab-based research into industry.  While following the COP26 in early November, I wrote a series of three posts focussed on energy consumption and the paradigm shifts required to slow down climate change.  There are some connections between these topics: viruses are nanoparticles whose transport and dynamics we do not fully understand; and, digital engineering tools are being used to explore zero-carbon approaches to, for example, energy generation and air transport.  The level of complexity, innovation and urgency associated with developing solutions to these challenges mean that there are always some unknowns and uncertainty when making associated decisions.

The links below are grouped by the topics mentioned above.  I expect there will be more on all of these topics in 2022; however, the topic of next week’s post is unknown because I have not written any posts in advance.  I hope that the uncertainty about the topic of the next post will keep you reading in 2022! 

Coronavirus pandemic: ‘Distancing ourselves from each other‘ on January 13th, 2021; ‘On the impact of writing on well-being‘ on March 3rd, 2021; ‘Collegiality as a defence against pandemic burnout‘ on March 24th, 2021; ‘It’s tiring looking at yourself‘ on March 31st, 2021; ‘Switching off and walking in circles‘ on April 7th, 2021; ‘An upside to lockdown‘ on April 14th, 2021; ‘A brief respite in a long campaign to overcome coronavirus‘ on June 23rd, 2021; and ‘It is hard to remain positive‘ November 3rd 2021.

Energy and climate change: ‘When you invent the ship, you invent the shipwreck‘ on August 25th, 2021; ‘It is hard to remain positive‘ November 3rd 2021; ‘Where we are and what we have‘ on November 24th, 2021; ‘Disruptive change required to avoid existential threats‘ on December 1st, 2021; and ‘Bringing an end to thermodynamic whoopee‘ on December 8th, 2021.

Innovation processes: ‘Slowly crossing the valley of death‘ on January 27th, 2021; ‘Out of the valley of death into a hype cycle?‘ on February 24th, 2021; ‘Innovative design too far ahead of the market?‘ on May 5th, 2021 and ‘Jigsaw puzzling without a picture‘ on October 27th, 2021.

Nanoparticles: ‘Going against the flow‘ on February 3rd, 2021; ‘Seeing things with nanoparticles‘ on March 10th, 2021; and ‘Nano biomechanical engineering of agent delivery to cells‘ on December 15th, 2021.

Uncertainty: ‘Certainty is unattainable and near-certainty is unaffordable‘ on May 12th, 2021; ‘Neat earth objects make tomorrow a little less than certain‘ on May 26th, 2021; ‘Negative capability and optimal ambiguity‘ on July 7th, 2021; ‘Deep uncertainty and meta ignorance‘ on July 21st, 2021; ‘Somethings will always be unknown‘ on August 18th, 2021; ‘Jigsaw puzzling without a picture‘ on October 27th, 2021; and, ‘Do you know RIO?‘ on November 17th, 2021.

Nano biomechanical engineering of agent delivery to cells

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figure 1 from [1] with text explanationWhile many of us are being jabbed in the arm to deliver an agent that stimulates our immune system to recognize the coronavirus SARS-CoV-2 as a threat and destroy it, my research group has been working, in collaboration with colleagues at the European Commission Joint Research Centre, on the dynamics of nanoparticles [1] [see ‘Size matters‘ on October 23rd, 2019] which could be used as carriers for the targeted delivery of therapeutic, diagnostic and imaging agents in the human body [2].  The use of nanoparticles to mechanically stimulate stem cells to activate signalling pathways and modulate their differentiation also has some potential [3]. In studies of the efficacy of nanoparticles in these biomedical applications, the concentration of nanoparticles interacting with the cell is a primary factor influencing both the positive and negative effects.  Such studies often involve exposing a monolayer of cultured cells adhered to the bottom of container to a dose of nanoparticles and monitoring the response over a period of time.  Often, the nominal concentration of the nanoparticles in biological medium supporting the cells is reported and used as the basis for determining the dose-response relationships.  However, we have shown that this approach is inaccurate and leads to misleading results because the nanoparticles in solution are subject to sedimentation due to gravity, Brownian motion [see ‘Slow moving nanoparticles‘ on December 13th, 2017] and inter-particle forces [see ‘ Going against the flow‘ on February 3rd, 2021] which affect their transport within the medium [see graphic] and the resultant concentration adjacent to the monolayer of cells.  Our experimental results using the optical method of caustics [see ‘Holes in fluids‘ on October 22nd, 2014] have shown that nanoparticle size, colloidal stability and solution temperature influence the distribution of nanoparticles in solution.  For particles larger than 60 nm in diameter (about one thousandth of the diameter of a human hair) the nominal dose differs significantly from the dose experienced by the cells.  We have developed and tested a theoretical model that accurately describes the settling dynamics and concentration profile of nanoparticles in solution which can be used to design in vitro experiments and compute dose-response relationships.

References

[1] Giorgi F, Macko P, Curran JM, Whelan M, Worth A & Patterson EA. 2021 Settling dynamics of nanoparticles in simple and biological media. Royal Society Open Science, 8:210068.

[2] Daraee H, Eatemadi A, Abbasi E, Aval SF, Kouhi M, & Akbarzadeh A. 2016 Application of gold nanoparticles in biomedical and drug delivery. Artif. Cells Nanomed. Biotechnol. 44, 410–422. (doi:10.3109/21691401.2014.955107)

[3] Wei M, Li S, & Le W. 2017 Nanomaterials modulate stem cell differentiation: biological
interaction and underlying mechanisms. J. Nanobiotechnol. 15, 75. (doi:10.1186/s12951-
017-0310-5)

Bringing an end to thermodynamic whoopee

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Two weeks ago I used two infographics to illustrate the dominant role of energy use in generating greenhouse gas emissions and the disportionate production of greenhouse gas emission by the rich [see ‘Where we are and what we have‘ on November 24th, 2021].  Energy use is responsible for 73% of global greenhouse gas emissions and 16% of the world’s population are responsible for 38% of global CO2 emissions.  Today’s infographics illustrate the energy flows from source to consumption for the USA (above), UK and Europe (thumbnails below).  In the USA fossil fuels (coal, natural gas and petroleum) are the source of nearly 80% of their energy, in the UK it is a little more than 80% and the chart for Europe is less detailed but the proportion looks similar. COP 26 committed countries to ending ‘support for the international unabated fossil fuel energy sector by the end of 2022’ and recognised ‘investing in unabated fossil-related energy projects increasingly entails both social and economic risks, especially through the form of stranded assets, and has ensuing negative impacts on government revenue, local employment, taxpayers, utility ratepayers and public health.’  However, to reduce our dependency on fossil fuels we need a strategy, a plan of action for a fundamental change in how we power industry, heat our homes and propel our vehicles.  A hydrogen economy requires the production of hydrogen without using fossil fuels, electric cars and electric domestic heating requires our electricity generating capacity to be at least trebled by 2050 in order to hit the net zero target. This scale and speed of  transition to zero-carbon sources is such that it will have to be achieved using an integrated blend of green energy sources, including solar, wind and nuclear energy.  For example, in the UK our current electricity generating capacity is about 76 GW and 1 GW is equivalent to 3.1 million photovoltaic (PV) panels, or 364 utility scale wind turbines [www.energy.gov/eere/articles/how-much-power-1-gigawatt] so trebling capacity from one of these sources alone would imply more than 700 million PV panels, or one wind turbine every square mile.  It is easy to write policies but it is much harder to implement them and make things happen especially when transformational change is required.  We cannot expect things to happen simply because our leaders have signed agreements and made statements.  Now, national plans are required to ween us from our addiction to fossil fuels – it will be difficult but the alternative is that global warming might cause the planet to become uninhabitable for us.  It is time to stop ‘making thermodynamic whoopee with fossil fuels’ to quote Kurt Vonnegut [see ‘And then we discovered thermodynamics‘ on February 3rd, 2016].

 

 

 

 

 

 

 

 

 

Sources:

Kurt Vonnegut, A Man without a Country, New York: Seven Stories Press, 2005.  He wrote ‘we have now all but destroyed this once salubrious planet as a life-support system in fewer than two hundred years, mainly by making thermodynamic whoopee with fossil fuels’.

US Energy flow chart: https://flowcharts.llnl.gov/commodities/energy

EU Energy flow chart: https://ec.europa.eu/eurostat/web/energy/energy-flow-diagrams

UK Energy flow chart: https://www.gov.uk/government/collections/energy-flow-charts#2020