Tag Archives: PhD opportunity

Digital twins and seeking consensus

A couple of weeks ago I wrote about our work on a proof-of-concept for a digital twin of a fission nuclear reactor and its extension to fusion energy [‘Digitally-enabled regulatory environment for fusion power plants‘ on March 20th, 2019].  In parallel with this work and together with a colleague in the Dalton Nuclear Institute, I am supervising a PhD student who is studying the potential role of virtual reality and social network analysis in delivering nuclear infrastructure projects.  In a new PhD project, we are aiming to extend this research to consider the potential provided by an integrated nuclear digital environment [1] in planning the disposal of nuclear waste.  We plan to look at how provision of clear, evidence-based information and in the broader adoption of digital twins to enhance public confidence through better engagement and understanding.  This is timely because the UK’s Radioactive Waste Management (RWM) have launched their new consent-based process for siting a Geological Disposal Facility (GDF). The adoption of a digital environment to facilitate a consent-based process represents a new and unprecedented approach to the GDF or any other nuclear project in the UK. So this will be an challenging and exciting research project requiring an innovative and multi-disciplinary approach involving both engineering and social sciences.

The PhD project is fully-funded for UK and EU citizens as part of a Centre for Doctoral Training and will involve a year of specialist training followed by three years of research.  For more information following this link.

Reference:

[1] Patterson EA, Taylor RJ & Bankhead M, A framework for an integrated nuclear digital environment, Progress in Nuclear Energy, 87:97-103, 2016.

Image: Artist’s impression of geological disposal facility from https://www.gov.uk/government/news/geological-disposal-understanding-our-work

 

Assessing nanoparticle populations in historic nuclear waste

Together with colleagues at the JRC Ispra, my research group has shown that the motion of small nanoparticles at low concentrations is independent of their size, density and material [1], [see ‘Slow moving nanoparticles‘ on December 13th, 2017].  This means that commercially-available instruments for evaluating the size and number of nanoparticles in a solution will give erroneous results under certain conditions.  In a proposed PhD project, we are planning to extend our work to develop an instrument with capability to automatically identify and size nanoparticles, in the range from 1 to 150 nanometres, using the three-dimensional optical signature, or caustic, which particles generate in an optical microscope, that can be several orders of magnitude larger than the particle [2],  [see ‘Toxic nanoparticles?‘ on November 13th, 2013].  The motivation for the work is the need to characterise particles present in solution in legacy ponds at Sellafield.  Legacy ponds at the Sellafield site have been used to store historic radioactive waste for decades and progress is being made in reducing the risks associated with these facilities [3].  Over time, there has been a deterioration in the condition of the ponds and their contents that has resulted in particles being present in solution in the ponds.  It is important to characterise these particles in order to facilitate reductions in the risks associated with the ponds.  We plan to use our existing facilities at the University of Liverpool to develop a novel instrument using simple solutions probably with gold nanoparticles and then to progress to non-radioactive simulants of the pond solutions.  The long-term goal will be to transition the technology to the Sellafield site perhaps with an intermediate step involving a demonstration of  the technology on pond solutions using the facilities of the National Nuclear Laboratory.

The PhD project is fully-funded for UK and EU citizens as part of a Centre for Doctoral Training and will involve a year of specialist training followed by three years of research.  For more information following this link.

References:

[1] Coglitore, D., Edwardson, S.P., Macko, P., Patterson, E.A., & Whelan, M.P., Transition from fractional to classical Stokes-Einstein behaviour in simple fluids, Royal Society Open Science, 4:170507, 2017.

[2] Patterson, E.A., Whelan, P., 2008, ‘Optical signatures of small nanoparticles in a conventional microscopeSmall, 4(10):1703-1706.

[3] Comptroller and Auditor General, The Nuclear Decommissioning Authority: progress with reducing risk at Sellafield, National Audit Office, HC 1126, Session 2017-19, 20 June 2018.

Spatial-temporal models of protein structures

For a number of years I have been working on methods for validating computational models of structures [see ‘Model validation‘ on September 18th 2012] using the full potential of measurements made with modern techniques such as digital image correlation [see ‘256 shades of grey‘ on January 22nd 2014] and thermoelastic stress analysis [see ‘Counting photons to measure stress‘ on November 18th 2015].  Usually the focus of our interest is at the macroscale, for example the research on aircraft structures in the MOTIVATE project; however, in a new PhD project with colleagues at the National Tsing Hua University in Taiwan, we are planning to explore using our validation procedures and metrics [1] in structural biology.

The size and timescale of protein-structure thermal fluctuations are essential to the regulation of cellular functions. Measurement techniques such as x-ray crystallography and transmission electron cryomicroscopy (Cryo-EM) provide data on electron density distribution from which protein structures can be deduced using molecular dynamics models. Our aim is to develop our validation metrics to help identify, with a defined level of confidence, the most appropriate structural ensemble for a given set of electron densities. To make the problem more interesting and challenging the structure observed by x-ray crystallography is an average or equilibrium state because a folded protein is constantly in motion undergoing harmonic oscillations, each with different frequencies and amplitude [2].

The PhD project is part of the dual PhD programme of the University of Liverpool and National Tsing Hua University.  Funding is available in form of a fee waiver and contribution to living expenses for four years of study involving significant periods (perferably two years) at each university.  For more information follow this link.

References:

[1] Dvurecenska, K., Graham, S., Patelli, E. & Patterson, E.A., A probabilistic metric for the validation of computational models, Royal Society Open Society, 5:180687, 2018.

[2] Justin Chan, Hong-Rui Lin, Kazuhiro Takemura, Kai-Chun Chang, Yuan-Yu Chang, Yasumasa Joti, Akio Kitao, Lee-Wei Yang. An efficient timer and sizer of protein motions reveals the time-scales of functional dynamics in the ribosome (2018) https://www.biorxiv.org/content/early/2018/08/03/384511.

Image: A diffraction pattern and protein structure from http://xray.bmc.uu.se/xtal/

Digitally-enabled regulatory environment for fusion powerplants

Digital twins are a combination of computational models and real-world data describing the form, function and condition of a system [see ‘Can you trust your digital twin?‘ on November 23rd 2016]. They are beginning to transform design processes for complex systems in a number of industries.  We have been working on a proof-of-concept study for a digital reactor in fission energy based on the Integrated Nuclear Digital Environment (INDE) [1].  The research has been conducted by the Virtual Engineering Centre (VEC) at the University of Liverpool together with partners from industry and national laboratories with funding from the UK Government for nuclear innovation.  In parallel, I having been working with a colleague at the University of Manchester and partners at the Culham Centre for Fusion Energy on the form of a digital environment for fusion energy taking account of the higher order of complexity, the scale of resources, the integration of novel technologies, and the likely diversity and distribution of organisations involved in designing, building and operating a fusion powerplant.  We have had positive interactions with the regulatory authorities during the digital fission reactor project and the culture of enabling-regulation [2] offers an opportunity for a new paradigm in the regulation of fusion powerplants.  Hence, we propose in a new PhD project to investigate the potential provided by the integration of digital twins with the regulatory environment to enable innovation in the design of fusion powerplants.

The PhD project is fully-funded for UK and EU citizens as part of a Centre for Doctoral Training and will involve a year of specialist training followed by three years of research.  For more information following this link.

References:

[1] Patterson EA, Taylor RJ & Bankhead M, A framework for an integrated nuclear digital environment, Progress in Nuclear Energy, 87:97-103, 2016.

[2] http://www.onr.org.uk/documents/2018/guide-to-enabling-regulation-in-practice.pdf

Image: https://www.pexels.com/photo/diagram-drawing-electromagnetic-energy-326394/