Tag Archives: nanoscopy

Assessing nanoparticle populations in historic nuclear waste

Together with colleagues at the JRC Ispra, my research group has shown that the motion of small nanoparticles at low concentrations is independent of their size, density and material [1], [see ‘Slow moving nanoparticles‘ on December 13th, 2017].  This means that commercially-available instruments for evaluating the size and number of nanoparticles in a solution will give erroneous results under certain conditions.  In a proposed PhD project, we are planning to extend our work to develop an instrument with capability to automatically identify and size nanoparticles, in the range from 1 to 150 nanometres, using the three-dimensional optical signature, or caustic, which particles generate in an optical microscope, that can be several orders of magnitude larger than the particle [2],  [see ‘Toxic nanoparticles?‘ on November 13th, 2013].  The motivation for the work is the need to characterise particles present in solution in legacy ponds at Sellafield.  Legacy ponds at the Sellafield site have been used to store historic radioactive waste for decades and progress is being made in reducing the risks associated with these facilities [3].  Over time, there has been a deterioration in the condition of the ponds and their contents that has resulted in particles being present in solution in the ponds.  It is important to characterise these particles in order to facilitate reductions in the risks associated with the ponds.  We plan to use our existing facilities at the University of Liverpool to develop a novel instrument using simple solutions probably with gold nanoparticles and then to progress to non-radioactive simulants of the pond solutions.  The long-term goal will be to transition the technology to the Sellafield site perhaps with an intermediate step involving a demonstration of  the technology on pond solutions using the facilities of the National Nuclear Laboratory.

The PhD project is fully-funded for UK and EU citizens as part of a Centre for Doctoral Training and will involve a year of specialist training followed by three years of research.  For more information following this link.

References:

[1] Coglitore, D., Edwardson, S.P., Macko, P., Patterson, E.A., & Whelan, M.P., Transition from fractional to classical Stokes-Einstein behaviour in simple fluids, Royal Society Open Science, 4:170507, 2017.

[2] Patterson, E.A., Whelan, P., 2008, ‘Optical signatures of small nanoparticles in a conventional microscopeSmall, 4(10):1703-1706.

[3] Comptroller and Auditor General, The Nuclear Decommissioning Authority: progress with reducing risk at Sellafield, National Audit Office, HC 1126, Session 2017-19, 20 June 2018.

Slow moving nanoparticles

Random track of a nanoparticle superimposed on its image generated in the microscope using a pin-hole and narrowband filter.

A couple of weeks ago I bragged about research from my group being included in a press release from the Royal Society [see post entitled ‘Press Release!‘ on November 15th, 2017].  I hate to be boring but it’s happened again.  Some research that we have been performing with the European Union’s Joint Research Centre in Ispra [see my post entitled ‘Toxic nanoparticles‘ on November 13th, 2013] has been published this morning by the Royal Society Open Science.

Our experimental measurements of the free motion of small nanoparticles in a fluid have shown that they move slower than expected.  At low concentrations, unexpectedly large groups of molecules in the form of nanoparticles up to 150-300nm in diameter behave more like an individual molecule than a particle.  Our experiments support predictions from computer simulations by other researchers, which suggest that at low concentrations the motion of small nanoparticles in a fluid might be dominated by van der Waals forces rather the thermal motion of the surrounding molecules.  At the nanoscale there is still much that we do not understand and so these findings will have potential implications for predicting nanoparticle transport, for instance in drug delivery [e.g., via the nasal passage to the central nervous system], and for understanding enhanced heat transfer in nanofluids, which is important in designing systems such as cooling for electronics, solar collectors and nuclear reactors.

Our article’s title is ‘Transition from fractional to classical Stokes-Einstein behaviour in simple fluids‘ which does not reveal much unless you are familiar with the behaviour of particles and molecules.  So, here’s a quick explanation: Robert Brown gave his name to the motion of particles suspended in a fluid after reporting the random motion or diffusion of pollen particles in water in 1828.  In 1906, Einstein postulated that the motion of a suspended particle is generated by the thermal motion of the surrounding fluid molecules.  While Stokes law relates the drag force on the particle to its size and fluid viscosity.  Hence, the Brownian motion of a particle can be described by the combined Stokes-Einstein relationship.  However, at the molecular scale, the motion of individual molecules in a fluid is dominated by van der Waals forces, which results in the size of the molecule being unimportant and the diffusion of the molecule being inversely proportional to a fractional power of the fluid viscosity; hence the term fractional Stokes-Einstein behaviour.  Nanoparticles that approach the size of large molecules are not visible in an optical microscope and so we have tracked them using a special technique based on imaging their shadow [see my post ‘Seeing the invisible‘ on October 29th, 2014].

Source:

Coglitore D, Edwardson SP, Macko P, Patterson EA, Whelan MP, Transition from fractional to classical Stokes-Einstein behaviour in simple fluids, Royal Society Open Science, 4:170507, 2017. doi: