Category Archives: fluid mechanics

From nozzles and diffusers to stars and stripes

Schematic diagram of explanation in textAt the end of a lecture on energy flows in my first year undergraduate course on thermodynamics, I talk about nozzles and diffusers as examples of practical applications of the rest of the material in the lecture.  It is hazardous to sit in the front row of the lecture theatre because I take in a water bottle with a trigger spray to demonstrate how the nozzle increases the velocity of the fluid at the expense of pressure while gently sprinkling water on the front row.  I am always intrigued by the symmetry of nozzles and diffusers.  Diffusers increase pressure of a fluid at the expense of its velocity, i.e., a mirror image of the action of a nozzle.  The cross-sections are also mirror images because a nozzle has a cross-section that decreases in the flow direction while a diffuser has a cross-section that increases in the flow direction.  At least for sub-sonic flows, because the shapes are reversed for super-sonic flow; so a sub-sonic nozzle looks like a super-sonic diffuser and a sub-sonic diffuser looks like a super-sonic nozzle.  If that all sounds like fluid mechanics then the thermodynamic message is that, in nozzles and diffusers, the rates of heat and work transfer are approximately zero while the change in the kinetic energy of the fluid is very large.  I finish the lecture with a video clip of a school quartet of trombones playing ‘Stars and Stripes Forever’ which wakes up the students who have slept through the lecture and allows me to point out the diffusers (bell of the trombone) transmitting acoustic pressure.

You can watch the video clip on YouTube at https://www.youtube.com/watch?v=mHw8P8NnUvI

The hills are shadows, and they flow from form to form, and nothing stands

Decorative aerial view of hillsThe title of this post comes from two lines in ‘In Memoriam A.H.H.‘ by Alfred, Lord Tennyson.  The theory of plate tectonics evolved about fifty years ago so it is very unlikely that Tennyson was thinking about the hills as waves of rock flowing across the landscape.  However, we now understand that Earth’s crust is divided into plates that are moving as a result of currents in the liquid magna beneath them.  For example, the African plate is moving northwards crashing into the Eurasian plate causing the edges of the plate to buckle and flow forming the Alps and Pyrenees along the edge of the Eurasian plate.  At the same time, the Eurasian plate is moving eastwards very slowly at a speed of about 2.5 cm per year, or about 2 metres in an average human lifetime.  So, nothing stands still.  Everything is a process.  It’s just that some processes are quicker than others [see ‘Everything is in flux but it’s not always been recognised‘ on April 28th, 2021].

Reference:

Helen Gordon, Notes from deep time, London: Profile Books, 2021.

Nano biomechanical engineering of agent delivery to cells

figure 1 from [1] with text explanationWhile many of us are being jabbed in the arm to deliver an agent that stimulates our immune system to recognize the coronavirus SARS-CoV-2 as a threat and destroy it, my research group has been working, in collaboration with colleagues at the European Commission Joint Research Centre, on the dynamics of nanoparticles [1] [see ‘Size matters‘ on October 23rd, 2019] which could be used as carriers for the targeted delivery of therapeutic, diagnostic and imaging agents in the human body [2].  The use of nanoparticles to mechanically stimulate stem cells to activate signalling pathways and modulate their differentiation also has some potential [3]. In studies of the efficacy of nanoparticles in these biomedical applications, the concentration of nanoparticles interacting with the cell is a primary factor influencing both the positive and negative effects.  Such studies often involve exposing a monolayer of cultured cells adhered to the bottom of container to a dose of nanoparticles and monitoring the response over a period of time.  Often, the nominal concentration of the nanoparticles in biological medium supporting the cells is reported and used as the basis for determining the dose-response relationships.  However, we have shown that this approach is inaccurate and leads to misleading results because the nanoparticles in solution are subject to sedimentation due to gravity, Brownian motion [see ‘Slow moving nanoparticles‘ on December 13th, 2017] and inter-particle forces [see ‘ Going against the flow‘ on February 3rd, 2021] which affect their transport within the medium [see graphic] and the resultant concentration adjacent to the monolayer of cells.  Our experimental results using the optical method of caustics [see ‘Holes in fluids‘ on October 22nd, 2014] have shown that nanoparticle size, colloidal stability and solution temperature influence the distribution of nanoparticles in solution.  For particles larger than 60 nm in diameter (about one thousandth of the diameter of a human hair) the nominal dose differs significantly from the dose experienced by the cells.  We have developed and tested a theoretical model that accurately describes the settling dynamics and concentration profile of nanoparticles in solution which can be used to design in vitro experiments and compute dose-response relationships.

References

[1] Giorgi F, Macko P, Curran JM, Whelan M, Worth A & Patterson EA. 2021 Settling dynamics of nanoparticles in simple and biological media. Royal Society Open Science, 8:210068.

[2] Daraee H, Eatemadi A, Abbasi E, Aval SF, Kouhi M, & Akbarzadeh A. 2016 Application of gold nanoparticles in biomedical and drug delivery. Artif. Cells Nanomed. Biotechnol. 44, 410–422. (doi:10.3109/21691401.2014.955107)

[3] Wei M, Li S, & Le W. 2017 Nanomaterials modulate stem cell differentiation: biological
interaction and underlying mechanisms. J. Nanobiotechnol. 15, 75. (doi:10.1186/s12951-
017-0310-5)

From strain measurements to assessing El Niño events

Figure 11 from RSOS 201086One of the exciting aspects of leading a university research group is that you can never be quite sure where the research is going next.  We published a nice example of this unpredictability last week in Royal Society Open Science in a paper called ‘Transformation of measurement uncertainties into low-dimensional feature space‘ [1].  While the title is an accurate description of the contents, it does not give much away and certainly does not reveal that we proposed a new method for assessing the occurrence of El Niño events.  For some time we have been working with massive datasets of measurements from arrays of sensors and representing them by fitting polynomials in a process known as image decomposition [see ‘Recognising strain‘ on October 28th, 2015]. The relatively small number of coefficients from these polynomials can be collated into a feature vector which facilitates comparison with other datasets [see for example, ‘Out of the valley of death into a hype cycle‘ on February 24th, 2021].  Our recent paper provides a solution to the issue of representing the measurement uncertainty in the same space as the feature vector which is roughly what we set out to do.  We demonstrated our new method for representing the measurement uncertainty by calibrating and validating a computational model of a simple beam in bending using data from an earlier study in a EU-funded project called VANESSA [2] — so no surprises there.  However, then my co-author and PhD student, Antonis Alexiadis went looking for other interesting datasets with which to demonstrate the new method.  He found a set of spatially-varying uncertainties associated with a metamodel of soil moisture in a river basin in China [3] and global oceanographic temperature fields collected monthly over 11 years from 2002 to 2012 [4].  We used the latter set of data to develop a new technique for assessing the occurrence of El-Niño events in the Pacific Ocean.  Our technique is based on global ocean dynamics rather than on the small region in the Pacific Ocean which is usually used and has the added advantages of providing a confidence level on the assessment as well as enabling straightforward comparisons of predictions and measurements.  The comparison of predictions and measurements is a recurring theme in our current research but I did not expect it to lead into ocean dynamics.

Image is Figure 11 from [1] showing convex hulls fitted to the cloud of points representing the uncertainty intervals for the ocean temperature measurements for each month in 2002 using only the three most significant principal components . The lack of overlap between hulls can be interpreted as implying a significant difference in the temperature between months.

References:

[1] Alexiadis, A. and Ferson, S. and  Patterson, E.A., , 2021. Transformation of measurement uncertainties into low-dimensional feature vector space. Royal Society Open Science, 8(3): 201086.

[2] Lampeas G, Pasialis V, Lin X, Patterson EA. 2015.  On the validation of solid mechanics models using optical measurements and data decomposition. Simulation Modelling Practice and Theory 52, 92-107.

[3] Kang J, Jin R, Li X, Zhang Y. 2017, Block Kriging with measurement errors: a case study of the spatial prediction of soil moisture in the middle reaches of Heihe River Basin. IEEE Geoscience and Remote Sensing Letters, 14, 87-91.

[4] Gaillard F, Reynaud T, Thierry V, Kolodziejczyk N, von Schuckmann K. 2016. In situ-based reanalysis of the global ocean temperature and salinity with ISAS: variability of the heat content and steric height. J. Climate. 29, 1305-1323.