Four years ago I wrote a post asking whether there were any fundamental laws of biology that are sufficiently general to apply beyond the context of life on Earth [‘Laws of biology?‘ on January 16th, 2016]. I suggested Dollo’s law that diversity and complexity increases in evolutionary systems; the Hardy-Weinberg law about allele and genotype frequencies remaining constant from generation to generation; and the Michaelis-Menten law governing enzymatic reactions. Recently, I came across a simpler statement of the laws of biology proposed by Edward O.Wilson. He states that the first law of biology is all entities and processes of life are obedient to the laws of physics and chemistry; and the second law is all evolution, beyond minor random perturbations due to high mutation rates and random fluctuations in the number of competing genes, is due to natural selection. It seems likely that these simpler laws will be universally applicable; however, until we find evidence of extra-terrestrial life, they will remain untestable in a universal context unlike the laws of physics.